Effects of Coenzyme Q10 on Biochemical Markers of Hepatic Necroinflammation in Patients with Nonalcoholic Fatty Liver

Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is a common metabolic liver disorder that can progress to cirrhosis. Up to now, there is no established treatment for this disease. Methods: We randomly assigned 55 adults with NAFLD to receive Coenzyme Q10 (CoQ10) 60 mg daily (30 subjects) or vitamin E 800 unit daily (25 subjects) for 3 months to assess the effect of CoQ10 versus vitamin E on BMI, ALT, AST, ALK-P, PT, Bilirubine, ALB, Ferritin, TG, Total Cholestrol, FBS, Serum Insuline, LDL, HDL, Total Anti Oxidant Capacity (TAC) before and after intervention. Results: In CoQ10 group there was a significant improvement in AST, ALT, TAC (P value<0.0001), Ferritin, Total bilirubin, GGT (p value<0.01), HDL (p value<0.05). In vitamin E group there was a significant improvement in AST, ALT, TAC, Ferritin, GGT, HDL (p value<0.01). There was not significant improvement in FBS, Insulin resistance and other lipid profile in both groups. Conclusion: Our study assigned that 60 mg CoQ10 is effective on improvement of noninvasive liver parameters in NAFLD. We suggest longer duration treatment and with larger dosage. We also suggest a large study with biopsy control for the assessment the effect of CoQ10 in NAFLD.


Sara Shafieipour, Ali Bahari, Mohammad Hashemi and Noorollah Hashemzehi

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