Effect of Particle Size of Nonsteroidal Anti-Inflammatory Drug on Lipopolysaccharide-Induced Inflammation on RAW264.7 Cells

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) have excellent anti-inflammatory and analgesic effects and are widely used in inflammatory diseases. In this study, mouse macrophage cells stimulated with Lipopolysaccharride were used as a model experiment to investigate the influence of NSAIDs particle size on the inflammatory response. Methods: RAW264.7 cells were used in this study. RAW264.7 cells, the survival rate was measured using the MTT method. Inflammation caused by using Lipopolysaccharride. The NSAIDs used were Indomethacin (IMC), ketprofen (KET), piroxicam (PXC), three kinds, and the antiinflammatory effect on the bulk powder and nano particles was evaluated. Evaluation of inflammation was based on inflammatory cytokines (IL-6, TNF-a) and NO production. Results: NSAID nano showed significant inhibitory effect on inflammatory cytokines (IL-6, TNF-a) and NO production compared with NSAIDbulk However, in NSAIDs with each particle size, no difference was found between the three drugs. Conclusion: This suggests that the NSAIDnano preparation may be a raw material for new drugs. In addition, it was suggested that NSAIDnano preparation could reduce the concentration of the drug.


Junko Yokota, Shiro Ishida, Atsuhide Hamada and Shojiro Kyotani

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