Oral route of administration have wide acceptance up to 50-60% to total drug forms. Fast disintegrating drug delivery system has number of advantage such as faster onset of action, attractive elegance, ease of administration. In this study, an attempt has been made to study compression method, for formulation of fast disintegrating tablets of Isoniazid and Rifampicin, anti-tubercular drugs in view of enhancing bioavailability. Prior to formulation the pre-compression parameters were characterized for flow properties and prepared formulations were evaluated for physico-chemical parameters, X-ray powder crystallography, SEM. All four formulations possessed good disintegration properties with total disintegration time of 25 to 40 seconds. The effects of Kollidon CL superdisintegrant and process variables on drug release profile and disintegration property were evaluated and results revealed the better drug release with Kollidon CL. All formulations are rapidly disintegrated in oral cavity as well as all formulations possess good anti-tubercular properties. SEM Showed the mechanical strength of the formulations affected the morphological changes after compression. Hence, it is evident from this study that fast dispersible tablets could be a promising delivery system for Isoniazid and Rifampicin combination with good mouth feel and improved drug availability with better patient compliance.