The purpose of present study is to evaluate the nephroprotector activity of the ethanolic and aqueous extracts of fruits of Pedalium murex (300 and 600mg/kg body weight, p.o.) against cadmium chloride-induced (3mg/kg/d s.c.) renal toxicity in rats. The effect of plant extracts were examined in terms of blood urea nitrogen, serum creatinine, urinary protein, urine to serum creatinine ratio, lipid peroxidation, gluthione,catalase in kidney.In present study, Cadmium induced nephrotoxicity characterized by significant elevation of serum markers levels, increased urinary protein excretion, raised LPO levels, reduced GSH and CAT levels, reduced creatinine clearance. Co-administration of either ethanolic or aqueous extract with CdCl2 was significantly prevented the renal injury in dose dependent manner. The present study provides the corroborative scientific evidence for the folklore use of Pedalium murex in urinary troubles.