Aims & objective-To compare the efficacy of Budesonide delivered by metered dose inhaler, metered dose inhaler with spacer and dry powder inhaler on the lung function test parameters. Materials and Methods: This prospective study was undertaken to assess the effect of budesonide administered from fifty patients of chronic stable bronchial asthma were budesonide(400mcg) by metered dose inhaler, metered dose inhaler with spacer and by dry powder inhaler at day 14, 21 and 28 after enrolment respectively under direct supervision. Pulmonary function test was done before and one hour after administration of the drug on each visit. Results: There was no evidence of difference in peak expiratory flow rate (P=0.20), forced expiratory volume in one second (P=0.98), forced vital capacity (P=0.57) and forced expiratory volume in one second and forced vital capacity ratio (P=0.34) was seen after giving budesonide by different devices. Conclusion: Budesonide delivered by metered dose inhaler, metered dose inhaler with spacer and dry powder inhaler have similar effect on lung function in patients of chronic stable bronchial asthma and may be used interchangeably.