Development of Spectrophotometric method for the Simultaneous estimation of Phenylephrine and Levocetirizine in Pharmaceutical dosage

A simple, accurate, rapid and precise spectrophotometric method has been developed for the simultaneous estimation of Phenylephrine and Levocetirizine in pharmaceutical dosage form. The method is based on UV spectrophotometric determination of two drugs, using Area under Curve method. It involves measurement of area under curve in the range of 271- 281 nm for Phenylephrine and 225-235nm for Levocetirizine. The linearity was observed in the concentration range of 2-10μg/ml for Phenylephrine and Levocetirizine. The accuracy of the method was assessed by recovery studies and was found to be 98.90 % and 98.0% for Phenylephrine and Levocetirizine respectively. The method showed good reproducibility and recovery with % RSD less than2. The method was found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of Phenylephrine and Levocetirizine in bulk and combined dosage form without any interference from the excipients. The method was validated according to ICH guidelines and was found to be satisfactory.

Author(s): Sunitha. P. G, Ilango. K

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