Development Of New Visible Spectrophotometric Methods For Quantitative Determination Of Almotriptan Malate As An Active Pharmaceutical Ingredient In Formulations

Purpose: The aim of the investigation was to see the simple and sensitive visible spectrophotometric methods for the determination of the almotriptan malate in bulk and tablet dosage forms. Methods: Two simple, sensitive and cost effective visible spectrophotometric methods (M1-M2) were developed for the estimation of almotriptan malate in bulk and dosage forms. The first method (M1) is based on the formation of blue reduced product by treating drug with Folin Ciocalteu (FC) reagent in the presence of sodium carbonate solution with an absorption maximum of 770nm. The second method (M2) is based on the complex formation product by drug with 1, 10-phenanthroline in the presence of Fe (III) as an oxidant in phosphoric acid medium with an absorption maximum of 510nm. Results: Beer’s law obeyed in the concentration range of 4-12μg/ml and 1-5 μg/ml for methodM1 and M2 respectively. No interference was observed from the usually existing additives in pharmaceutical formulations and the applicability of the methods was examined by analyzing AXERT tablets containing AM. Conclusion: The reported methods for its assay involve sophisticated equipment, which are very costly and pose problems of maintenance. To overcome these problems, the use of visible spectrophotometric technique is justifiable. The statistical data proved the accuracy, reproducibility and the precision of the proposed methods.

Author(s): U. Viplava Prasad, M. Syam Bab, B. Kalyana Ramu

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