Development, Evaluation and Characterization of surface solid dispersion for solubility and dissolution enhancement of Irbesartan

The objective of the present study was to formulate Surface solid dispersions (SSD) of Irbesartan to improve the solubility and dissolution rate to facilitate faster onset of action. Irbesartan is a BCS-II drug having low solubility and low availability. In the present study, SSD’s of Irbesartan with four different superdisintegrants (Crospovidone, Croscarmellose sodium, Sodium starch glycolate, Pre-gelatinized starch) with five different drug-carrier ratios were prepared by solvent evaporation method. SSD’s were characterized by assay & content uniformity, FT-IR studies, PXRD (Powder X- ray diffractometry, DSC (differential scanning calorimetry), Gas chromatography and in vitro dissolution studies. The dissolution profile of prepared dispersion of Irbesartan: SSG in 1:7 ratio were faster compared to other carriers, DSC studies revealed that there was no interaction between drug: carrier where as the PXRD demonstrated that there was a significant decrease in crystallinity of pure drug present in the surface solid dispersions, which resulted in an increased dissolution rate of Irbesartan.

Author(s): Anand Kumar Meka, Santhosh Pola, Karnaker Reddy Tupally, Prasanna Lakshmi Abbaraju

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