Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF ITRACONAZOLE BULK DRUG AND PHARMACEUTICAL FORMULATION

An UV spectrophotometric method for the quantitative determination of Itraconazole, a highly potent antimycotic, in capsule was developed in present work. The parameters linearity, precision, accuracy, limit of detection and limit of quantitation were studied according to International Conference on Harmonization guidelines. UV spectroscopic determination was carried out at an absorption maximum of 262 nm using methanol as solvent. In the UV spectroscopic method linearity over the concentration range of Itraconazole was found to be 4-14


Author(s): Shalin K. Parikh, Ankit D. Patel, Dr. J. B. Dave, Dr. C. N. Patel and Dr. D. J. Sen

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