A simple, accurate, rapid and precise spectrophotometric method has been developed for simultaneous estimation of Lafutidine and Domperidone in pharmaceutical dosage form. This method was based on UV spectrophotometric determination of two drugs, using Area under Curve method. It involves measurement of area under curve in the range of 268-278 nm (For Lafutidine) and 282.2-292.2 nm (For Domperidone) for the analysis in methanol. The linearity was observed in the concentration range of 2-12 μg/ml for Lafutidine and 3-18 μg/ml for Domperidone. The method showed good reproducibility and recovery with % RSD less than 2. Method was found to be rapid, specific, precise and accurate, can be successfully applied for the routine analysis of Lafutidine and Domperidone in bulk, and combined dosage form without any interference by the excipients. The method was validated according to ICH guidelines.