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Development and Validation of RP-HPLC method for the Simultaneous estimation of Meloxicam and Paracetamol

A novel, rapid, sensitive, specific RP-HPLC method was developed and validated for the simultaneous estimation of meloxicam and paracetamol in bulk and its dosage form. Efficient chromatographic separation was achieved on a Hypersil ODS C18 (150mm * 4.6mm, 5.0μm) column containing UV-Visible detector with methanol and water as mobile phase in the ratio of 70:30 at a flow rate of 0.6ml/min and the eluent was monitored at 240nm. Retention times were found to be 3.5min and 5.0min for meloxicam and paracetamol respectively. Results of the analysis were validated statistically and by recovery studies. The developed method has shown to be linear (r2 = 0.939 for Mlx and 0.996 for Pct), precise (R.S.D < 2), accurate (recovery of 99.26% for Mlx and 94.96% for Pct) and specific with limit of detection (0.102 for Pct and 0.591 for Mlx) and limit of quantitation (0.310 for Pct and 1.79 for Mlx) as per ICH guidelines

Author(s): K. Naga Raju, T. Sunitha, V. Krishnaja, I. Sudheer Babu

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