Abstract

Development and Validation of RP-HPLC method for the estimation of Zileuton in bulk and its dosage form

A simple, economical, sensitive, specific, precise and accurate RP-HPLC method was developed and validated for determination of Zileuton in bulk and pharmaceutical dosage form. Chromatography was carried on an Enable C18 G 250 x4.6 mm column using filtered and degassed mixture of methanol and water (70: 30 v/v) as mobile phase at a flow rate of 1.0 ml/min in isocratic mode and effluent was monitored at 229 nm. The retention time for zileuton was found to be 3.5 min. The method was linear over the concentration range of 5-30 Cg/ml with correlation coefficient 0.999. Proposed method was validated for specificity, precision, accuracy, linearity, robustness.


Author(s): Vara Prasada Rao K, Tanuja M, Srinivasa Rao Y, Hemant Kumar T

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
30+ Million Readerbase
Recommended Conferences
Flyer image
Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • MIAR
  • ResearchGate
  • University Grants Commission
  • Secret Search Engine Labs

tempobet

tempobet giriş

tempobet giriş

tipobet süpertotobet yeni adres süperbahis 747 güvenilir bahis siteleri telefonda sex sohbet