Reach Us 44-7452-259145

Abstract

Development and Validation of RP-HPLC method for quantification of Valsartan and its Pharmaceutical Formulations

A simple, rapid, sensitive, reverse phase isocratic RP-HPLC method was developed for determination of Valsartan and its pharmaceutical formulation. The method was carried out using C18 column [Agilent ODS UG 5 column, 250mm x 4.5mm] with mobile phase comprised of Acetonitrile: Phosphate buffer (70:30 v/v) with 1.0 ml / min flow rate was quite robust. The optimum wavelength for detection was 273 nm at which better detector response for the drug was obtained. The run time was set at 7 min and the retention time was 3.5 minutes. The method was validated for specificity, accuracy, precision, linearity, limit of detection, limit of quantification, robustness, solubility and stability. LOD and LOQ were found to be 1.83 μg/ml, 5.5 μg/ml respectively. The calibration curve was linear in the concentration range of 10-50 μg/ml with coefficient of correlation 0.9993. The percentage recovery for the valsartan was found to be 99.0-100.2 and the % RSD was found to be less than 2 %. The proposed method was successfully applied for quantitative determination of valsartan in tablet dosage forms.


Author(s): Nagakanyaka devi paladugu*, G. Devala Rao, Bonthu Satyanarayana, Deepthi Poloju

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
30+ Million Readerbase
Recommended Conferences
Google scholar citation report
Citations : 7538

International Journal of Drug Development and Research received 7538 citations as per google scholar report

International Journal of Drug Development and Research peer review process verified at publons
Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • MIAR
  • ResearchGate
  • University Grants Commission
  • Secret Search Engine Labs
  • Euro Pub

View More »

Flyer image

tempobet

tempobet giriş

tempobet giriş

tipobet süpertotobet yeni adres süperbahis 747 güvenilir bahis siteleri telefonda sex sohbet
https://wowcappadocia.com
https://cappadocia-hotels.com
https://balloon-rides.net

https://paperio-live.com

rolex replica

https://agario.red

https://naughtyworms.com

Vaporesso
Smok
https://www.unitedluxury.net/