Abstract

DEVELOPMENT AND INVITRO EVALUATION OF FAST DISSOLVING TABLETS OF GLICLAZIDE

In the present work, fast dissolving tablets of gliclazide were prepared by direct compression method with a view to enhance patient compliance. Two superdisintegrants viz, crospovidone and croscarmellose sodium (4%, 5%, 6%) with different binders viz, Polyvinyipyrolidone K-30 and pregelatinized starch (3%) were used. The prepared batches of tablets were evaluated for hardness, friability, weight variation, disintegration, wetting time, drug content and in vitro dissolution studies. Based on evaluating parameters, Formulation prepared by using 5% croscarmellose sodium with 3% PVP K30 was selected as optimized formulation. Finally, the optimized formulation was compared with marketed conventional formulation. Stability studies were carried out at 25ºC / 60% RH and 40ºC / 75% RH for optimized formulation for 2 months. Stability studies on the optimized formulation indicated that there was no significant change found in physical appearance, disintegration time and wetting time of the tablets.


Author(s): Shinde Anilkumar J., Paithane Manoj B., More Harinath. N.

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