The purpose of the present research was to design fast melting tablets of donepezil hydrochloride. FMT?s were prepared by direct comperession using different superdisintegrants. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro and in-vivo dispersion, mouth feel and in vitro dissolution. All the formulations showed low weight variation with dispersion time less than 30 seconds and rapid in vitro dissolution. The drug content of all the formulations was within the acceptable limits. This work helped in understanding the effect of formulation processing variables on the drug release profile. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.