Development & Optimization of Pectin microsphere of Metformin HCL

To develop & optimize the pectin microspheres of Metformin hydrochloride. Solvent evaporation method used in the microencapsulation process. Concisely the polymer ethyl cellulose (500mg) was dissolve in 40 ml of ethanol to get a clear solution. The drug Metformin (500mg) was added and dissolved in the polymer solution. The resultant mixture was then stirred at 900 r.p.m for 2 hr to evaporate the volatile substance. The formed microspheres were collected and air dried for 3hr and stored in desiccators for further use. The percentage yield of all the formulations was found to be satisfactory. It can be due to the involvement of process parameters. Drug entrapment efficiency (DEE) of F2 formulation found to be high because, the drug is fully dispersed in the polymer phase by continuous stirring for a longer period. The particle size of all the formulations found to be satisfactory and within the range of (34.56 to71.34μm). Particle sizes of the formulations prepared by W/O emulsion solvent evaporation method are within the range of 34.02 μm and that formulation prepared by solvent evaporation method were within the range of 39.64 to 48.21 μm. FT-IR spectra for the drug were recorded and it was compared against the FT-IR spectra of the formulated drug along with the polymer. Metformin gives characteristics peaks at wave number 1254,1473,1620,3270 and 3288. The peak at 1254 corresponds to the C-N stretching, 1473 to C-H stretching 1620 to c=c stretching, where as the peak at 3270 and 3288 corresponds to –NH stretching. Thus FT-IR studies revealed that there was no shift in peaks of the formulation, thus indicating there was no interaction between drug and other polymers used. Pectin microspheres of metformin hydrochloride prepared by solvent evaporation method showed good entrapment property with well release characteristics and there no interaction drug and excipients is observed.

Author(s): Konar Sanjoy, Dutta Roy Swagata, Sahoo Himanshu Bhusan, Nandy Subhangkar

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