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Design, Development And Evaluation Of Aceclofenac Sustained Release Matrix Tablets

In the present study “once daily” sustained release tablet of Aceclofenac has been developed. The study was designed to formulate, develop and evaluate an Aceclofenac sustained release tablets using HPMC of various grades as polymer as release retarding agent. Preformulation study of Aceclofenac was done initially and results directed for the further course of formulation. Based on preformulation studies different batches of tablet have been prepared by wet granulation method by using selected excipients. Granules were evaluated for various tests before being punched as tablets. Tablets were tested for weight variation, thickness, hardness and friability as per official procedure. Dissolution of batch T-8 was carried out in phosphate buffer pH 6.8 media and compared with marketed preparation. Based on dissolution tests and F-2 (similarity factor) values in pH 6.8 phosphate buffer as release medium, it was concluded that T-8 satisfactory performs in the same manner as that of marketed formulation. F-2 (similarity factor) value of T-8 was found to be optimized. From the results obtained it is concluded that formulation of sustained release tablet of Aceclofenac containing HPMC K 15M in the ratio of 200: 23 (in mg), T8 can be taken as an ideal or optimized formulation of sustained release tablets for 24 hour release as it fulfills all the requirements for sustained release tablet. The drug release from these formulations was satisfactory after 2 months storage in 400 C and 75% RH. Besides, this study explored the optimum concentration and effect of polymer(s) on acelofenac release pattern from the tablet matrix for 24 hour period

Author(s): Sharma Ankita, Shukla Tarkeshwar, Indoria Manish Dev, Jha Sajal Kumar

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