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Abstract

Design and Development of Nifedipine Extended Release Tablet Double Rotary Bi- Layered Compression Machine

The aim of the present work was to Design and development of Nifedipine extended release tablet 90 mg by double rotary bi layered compression machine that can provide continuous drug release for period of 24 hours. The granules prepared using polymers such as polyethylene glycol 4000, HPMC and cellulose acetate etc. the osmotic pump mechanism was used, after that mechanical drilling machine was used for drilling with respect in size. Prior to compression, the prepared granules were evaluated for flow and compression characteristics. The principle shows two compartments was present such as the drug layer and push layer, after some time push layer goes contact with aqueous medium then swelling of push layer and suspend drug particle and flow through the delivery orifice. Prepared Nifedipine extended release tablet was evaluated for in vitro drug release study. The prepared Nifedipine extended release tablet 90 mg showed good mechanical properties (hardness and friability) as well as good in vitro dissolution profile showing the release of constant drug for 24 hours. The increase in binder has retarding effect leading to the decrease in the dissolution. The Change in granulation time with respect to increase in parameters.


Author(s):

Sunita S Shinde*, Sharad K Kamble and Manohar D Kengar



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