The present study was carried out to determine the radical scavenging and anticaries activity of methanol extract of leaf and seed of Anisomeles indica Linn. (Lamiaceae). Total phenolic and flavonoid content of leaf and seed extract were determined by Folin-Ciocalteau Reagent method and Aluminium chloride colorimetric estimation method respectively. Radical scavenging activity of different concentrations of leaf and seed extracts was evaluated by DPPH free radical scavenging assay. Anticaries activity of leaf and seed extracts was performed against six clinical isolates of Streptococcus mutans by Agar well diffusion assay. The content of total phenolics and flavonoids were higher in leaf extract when compared to seed extract. Both the extracts scavenged DPPH radical in a dose dependent manner. Leaf extract was more efficient in scavenging radicals (IC50 2.70μg/ml) than seed extract (IC50 8.18μg/ml). Similarly, leaf extract inhibited S. mutans isolates to higher extent than seed extract. A marked radical scavenging and anticaries activity of leaf and seed extract of A. indica was observed in this study. Leaf extract was more efficient in scavenging DPPH radicals and inhibiting the S. mutans isolates. The high phenolic and flavonoid content of leaf extract might be attributed to higher radical scavenging and antibacterial activity.