Abstract

COMPARATIVE CARDIOTONIC ACTIVITY OF AEGLE MARMELOS JUICE WITH DIGOXIN ON ISOLATED FROG HEART

Aegle marmelos (L.) (Rutaceae) commonly known as bael. Phytochemical studies had revealed the presence of tannins, saponins, sesquiterpenes, alkaloids and phlobatamins. The juice was claimed to have general cardiotonic activity. Present study was carried out to determine the same by using fresh fruit juice with different dilutions & compared with cardiotonic activity of digoxin-the life saving cardiotonic. The activity was tested by using isolated frog heart assembly. The present preliminary studies confirm the better cardiotonic activity of Aegle marmelos than digoxin. Further studies can confirm the reduced toxicity & this will be the advantage of Aegle marmelos over digitalis. Thus, in future it will be interesting to isolate the active chemical constituents which are responsible for the cardiotonic activity.


Author(s): Dama G.Y., Tare H.L., Gore M.S., Shende V.S., Deore S.R., Bidkar J.S., Gorde P.V.

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