Combination of Natural Agent with Synthetic Drug for the Breast Cancer Therapy

Introduction: Breast cancer is the major cause of death worldwide. Urgently treatment is needed. A number of undesired side effects sometimes occur during the conventional therapy of cancer. Bioactive compounds derived from plant are the most popular alternative medicine which may reduce adverse effects. Various herbal compounds have been identified and showed very promising anti-cancer properties.

Methodology: The review was systematically conducted by searching the databases of MEDLINE, PubMed, Web of Knowledge, Google Scholar and Science Direct for original research articles and books using relevant search terms.

Results: The potential of combining phytomedicine or natural products with synthetic drugs or introducing these into conventional treatment regimens are not yet systematically explored. Combinatorial strategy may hold promise in development of therapies and chemoprevention strategies against ER-positive breast tumors.

Discussion: The screening for synergetic effects of such combinations is technically demanding and complex, also in the context of drug/herb interactions, but likely to substantially advance pharmacotherapy and future medicine.

Conclusion: It has been concluded that combined effect may improve the treatment effectiveness in combating proliferation of cancer cells, enhancing therapeutic efficacy, as well as abrogating drug resistance.


Bharti Mangla and Kanchan Kohli

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