The present study was designed to investigate the antiulcer and anti-inflammatory potential of ethanolic extracts of Polyalthia longifolia and aqueous extracts of Polyalthia longifolia. Antiulcer activity was evaluated by pylorus ligation, aspirin induced and ethanolic induced ulcer models. Effect of concurrent administration of ethanolic and aqueous extracts of leaves extract Polyalthia longifolia at dose of 200 and 300 mg/kg b.w. respectively was given by oral route. Ethanolic and aqueous extracts of Polyalthia longifolia dose dependently decrease gastric content, total acidity, ulcer index, and increase in pH of gastric pylorus ligation ulcer model. Antiinflammatory activity was performed using Cotton pellet granuloma in rats. Ethanolic and aqueous extracts of higher dose (300 mg/kg) being the most active, exhibited maximum antiinflammatory activity. Extracts of Polyalthia longifolia may be useful as a natural antioxidant in the treatment of ulcer, inflammation and pain.