Hyperlipidemia is the greatest risk factor of coronary heart disease. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidemia has no side effects and is relatively cheap and locally available. Based on high Glycoside content in herbal plants, Picrorhiza kurroa was selected and the present study focus on the anti-hyperlipidemic activity. The alcoholic,chloroform and aqueous root extracts of Picrorhiza kurroa Royle ex Benth were screened for its antihyperlipidemic activity in Triton wr- 1339 induced albino rats. Atorlip-20 was used as reference standard. The results showed significant decrease in triglyceride and cholesterol level when compared with the hypolipemic groups by using different dose: low (50mg/kg), high (200mg/kg) and standard Atorlip-20(4mg/kg bw) and by treating for 7 hr and 24 hr.