Abstract

Antifungal activity of flavonoids of Sida acuta Burm f. against Candida albicans

Sida acuta, is a common weed plant belonging to the family Malvaceae. In the present study free and bound flavonoids of different parts of S. acuta have been evaluated for their antifungal activities using disc diffusion assay, against Candida albicans (MTCC No. 183). Minimum inhibitory concentration (MIC) of the extract was evaluated by microbroth dilution method, while minimum fungicidal concentration determined by subculturing the relevant samples. The plant exhibited good antifungal activity against tested fungi. Among 8 extracts tested 7 were found to be active at tested concentration. Free flavonoids were found to be more potent than bound flavonoids. Total activity (TA) was calculated for the extracts, to relate MIC of the extracts with its amount isolated from 1 g dried plant part. The study showed that flavonoids of S. acuta can be exploited for future anticanadidal drug.


Author(s): Jindal Alka, Kumar Padma, Jain Chitra

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