Aim and objective: Leucas cephalotes is traditionally used as an emmenagogue. The present aim of the study is to evaluate and explore the antifertility effect of chloroform and alcoholic flowers extract of Leucas cephalotes. Material and method: Using soxhlet, extraction for 48 hrs with solvents chloroform and ethanol, flower extract was prepared. Anti-implantation, estrogenic and anti-estrogenic activities were evaluated using albino female rat animals. Result and conclusion: The chloroform and alcoholic extract was found to be more potent in causing significant anti-implantation activity at the tested dose of 200 mg/kg and 400 mg/kg body weight. The extracts further showed more significant increase in uterine weight in immature ovariectomised rats. It revealed that administration of extract with ethinyl estradiol causing significant anti-estrogenic activity. Thus it can be concluded that chloroform and alcoholic extract of Leucas cephaloteshas antifertility activity.