Anti Urolithiatic activity of Extracts of Aerva javanica in Rats

In the indigenous system of medicine in India, the plant Aerva javanica commonly termed as Tella burga is claimed to be useful for various ailments, and one such use is for the treatment of renal calculi. The major purpose of this study is to investigate the potential activity of Aerva javanica in the treatment of renal calculi. Urolithiasis is the process of development of crystal in the urinary tract. Wistar rats were taken and they are divided into nine groups. The first group used as normal and remaining groups received ethylene glycol 0.75% by orally for 28days. Second group received ethylene glycol Group-III received cystone (750mg/kg) till 28th day. Groups IV, V, VI and VII, VIII and IX served as preventive regimen received Aerva javanica aqueous extract, methanolic extract and ethyl acetate extract (200mg/kg and 400mg/kg) per oral respectively from 1st day till 28th day. On the 28th day of experiment animals were housed in metabolic cages and 24 hours urine samples and serum samples were collected. The urine was subjected to microscopical study to observe the crystals. The parameters monitored in the present study are uric acid, creatinine, sodium, potassium, magnesium oxalates and calcium in urine and serum samples. Ethylene glycol feeding resulted in hyperoxaluria as well increased renal excretion of calcium and oxalates. Treatment with aqueous, methanol and ethyleacetate extract of Aerva javanica roots significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The increased deposition of stone forming constituents in the serum and urine of calculogenic rats was also significantly lowered


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