Anti Ulcer activity of Pterospermum acerifolium (L) Willd leaves and its combined effect with H2 Blocker and Proton Pump Inhibitor

The present study was performed to evaluate the antiulcerogenic activity of methanolic extract of Pterospermum acerifolium leaves by pyloric ligation described by shay et al in rats. Effect of different doses of methyl extract of Pterospermum acerifolium leaves, famotidine and omeprazole on volume of gastric secreation, pH, free acid, total acid and ulcer index were observed. In addition, the effect of low dose of methanolic extract of Pterospermum acerifolium leaves in combination with low dose of famotidine and omeprazole on the above parameters were studied. Methanolic extract of Pterospermum acerifolium (200 and 400mg/kg), famotidine (4mg/kg) and omeprazole (4mg/kg) produced significant antiulcer effect. Low doses of famotidine, omeprazole and Methanolic extract of Pterospermum acerifolium did not alter above parameter significantly. Combined administration of low dose of famotidine, omeprazole with Methanolic extract of Pterospermum acerifolium shows significant antiulcer effect where the reduction of gastric secreation, acidity and ulcer index with simultaneous increase in gastric pH.

Author(s): Katare Vivekanand , Datta Rana, Chakraborty Bodhisattwa and Nandy Subhangkar

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