Analytical method development and Validation for the Quantitative estimation of Cefditoren Pivoxil in tablet formulation by RP-HPLC

A simple and accurate RP-HPLC method has been developed for the estimation of Cefditoren Pivoxil in tablet pharmaceutical dosage form using C18 Nucleosil column 150 x 4.6 mm i.d, 5 μm particle size in isocratic mode with mobile phase comprising of phosphate buffer (pH 3.0), acetonitrile and methanol in the ratio of 50:25:25 v/v. The flow rate was 1.0 ml/min and detection was carried out by UV-PDA detector at 230 nm. The retention time for Cefditoren Pivoxil was found to be 4.2 min. The linearity range, correlation co-efficient and accuracy of Cefditoren Pivoxil was found to be 40 -360 μg/ml, 0.9999 and 99.21% respectively. The developed method was found to be simple, precise and accurate for the estimation of Cefditoren Pivoxil in tablet formulations.

Author(s): S.Vidhya, B.Lakshmi Narayanan, P.Malairajan, R.Joseph Sahayaraja, E.P.Kumar, S.Mahibalan, M.Karpakavalli, C.Balakumar

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