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Aminobiphosphonates in Osteoporosis: A Review

Osteoporosis is a disease of great social impact, in recent years has assumed increasing importance, due to the progressive ageing of the population and the consequent increase of its complications, first of all femoral and vertebral fractures. Various treatment strategies has been employed to overcome, Aminobiphosphonate is one of them & they represents a major advance in the treatment of musculoskeletal disorders and they are now amongst the most commonly used agents in clinical practice. Bisphosphonates are analogues of inorganic pyrophosphate and are inhibitors of bone resorption. Many derivatives have been developed for the treatment of enhanced bone resorption. In this review, we explore the potential applications of that concept by summarizing the bone diseases and candidate proteins that will benefit from the proposed bone delivery approach. A selective synopsis of BP synthesis is presented to highlight the synthesis of functional BPs suitable for covalent attachment to proteins.

Author(s): Nadim M. R. Chhipa, Dhrubo Jyoti Sen

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