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Abstract

A Simple and Rapid Spectrophotometric Determination of Aripiprazole in Pharmaceutical Dosage Form

A new simple, sensitive, spectrophotometric method in ultraviolet region for the determination of aripiprazole in bulk and pharmaceutical dosage forms was developed. Spectroscopic determination was carried out at an absorption maximum of 256 nm using 95% ethanol as solvent. In the UV spectroscopic method linearity over the concentration range of aripiprazole was found to be 5 ? 30 µg/ml with a correlation coefficient 0.9995. Results of the analyses were validated statistically and by recovery studies. The developed method was found to be precise, selective and rapid for the estimation of aripiprazole in solid dosage form.


Author(s): Samiran Dey , Nitesh Chauhan,Dr. P. Malairajan, R. Murugan , Rakhal Chandra Das, Shafique Ahmad

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