Objective: In the present investigation, MPC of Sulbactomax was compared with ceftriaxone+sulbactam and ceftriaxone against ESBL producing Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Proteus vulgaris, Escherichia coli and Citrobacter braakii. Methods:The MPC of each antibacterial agent was determined using agar dilution method with a final inoculum size of 1010 CFU/ml of each organism. Result: The Sulbactomax MPC for ESBL organisms was in the range from 32 to 128 μg/ml and for ceftriaxone+sulbactam and ceftriaxone, it ranged from >256 and >512, respectively. The results suggest that Sulbactomax is highly efficacious in-vitro against selected ESBL producing organisms with lower MPC values, when compared with the ceftriaxone+sulbactam and ceftriaxone. Conclusion: Sulbactomax is one of the best choice to treat the infections caused by the above said ESBL producing micro-organisms, indicating to be effective in the prevention of disease caused by these ESBL organisms.