Traditionally, drugs are released in an immediate or extended manner. A pulsatile drug release, where the drug is released rapidly after a well defined lag-time, could be advantageous for many drugs or therapies. As the pulsatile drug delivery achieve desired therapeutic effect and reducing side effect, so patient compliance can be obtained along with lowering dose frequency. These systems are designed according to the circadian rhythm of the body and the drug is released as a pulse. Diseases like asthma, peptic ulcers, cardiovascular ailments, arthritis and attention deficit syndrome in children and hypercholesterolemia can be cured by drugs, released by PDDS. Recent trends include Multiparticulate drug delivery systems that are especially suitable for achieving controlled or delayed release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time. Various methods and marketed technologies of PDDS such as Pulsincap TM, Diffucaps, CODAS, OROS and PULSYSTM are covered in this review.