50. Development of Solid Self Micro Emulsifying Drug Delivery System with Neusilin US2 for Enhanced Dissolution Rate of Telmisartan

Aim of present study was to develop solid self micro emulsifying drug delivery system (S-SMEDDS) with Neusilin US2 for enhancement of dissolution rate of Telmisartan (TEL). SMEDDS was prepared using Oleic acid, Tween 80 and PEG 400 as oil, surfactant and cosurfactant respectively. For formulation of stable SMEDDS, micro emulsion region was identified by constructing pseudo ternary phase diagram containing different proportion of surfactant: co-surfactant (Km value 1:1, 2:1 and 3:1), oil and water. Prepared SMEDDS was evaluated for thermodynamic stability study, dispersibility tests, globule size and zeta potential. S-SMEDDS was prepared by adsorption technique using Neusilin US2 as solid carrier. Prepared S-SMEDDS was evaluated for flow properties, drug content, reconstitution properties, FTIR, SEM, DSC and in-vitro dissolution study. Results showed that prepared liquid SMEDDS passed dispersibility test with good thermodynamic stability. Globule size was found to be 30.2 nm with polydispersity index 0.116 and -5.80 mV zeta potential. S-SMEDDS showed good flow property and drug content. Reconstitution properties of S-SMEDDS showed spontaneous micro emulsification with globule size 32.4 nm and polydispersity index 0.219 and -6.32 mV zeta potential. Results of in-vitro dissolution showed that there was enhancement of dissolution rate of TEL as compared with that of plain TEL. From the results study concluded that, Neusilin US2 can be used to develop S-SMEDDS by adsorption technique to enhance dissolution rate of poorly water soluble drug such as TEL.

Author(s): Bhagwat Durgacharan A, DSouza John I

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