44. Designing, Synthesis and Biological Evaluation of some 5-mercapto Pyrimidine Derivatives

The pyrimidine derivatives are the hetero cyclic compounds with having potent biological activities such as antibacterial, anti-inflammatory and analgesic,, antifungal and antihypertensive.The 5- marcapto pyrimidine moiety was synthesized by the cyclo condensation reaction between substituted thiazolidin-4-ones moiety and thiourea after insilico modeling with the target molecules (receptors like-3GI9,3FHU,4AE5 and 4COX).The energy minimization ,bond lengths and bond angles of the synthesized compounds were done in Argus Lab-5.3 and the docking results were performed by Hex-6.3 software with macro target molecules. These compounds were screened for their antibacterial and anti inflammatory activities. The zone of inhibition of these compounds was promising as compared to the standard while the anti inflammatory activity was done by protein denaturing method.

Author(s): Rajkumar Mohanta and Susant Kumar Sahu

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