Problems related to safety, efficacy & quality of medicines exists in many places around the world today, not just developing countries but in developed countries as well. Counterfeiting can apply to both branded and generic products and counterfeit products include products with correct ingredients or with fake packaging. Counterfeit drugs may lead to death in severe cases such as heart attack, epilepsy, angina pectoris, in such condition anti-counterfeit drugs acts as weapon to avoid tragedy. It is very difficult to identify counterfeits from genuine products. Hence anti-counterfeit packaging techniques such as 2-D barcodes, holograms & Radio frequency identification overt, or visible features, covert, or hidden markers, forensic techniques, and serialisation/track and trace can be used to protect patient from counterfeit medicines.