Floating drug delivery system is a recent advancement in pharmaceutical technology which has also several advantages over the conventional drug delivery systems. Those advantages of floating system can be used in the treatment of world’s most affective diseases like cardiovascular diseases. Cardiovascular diseases are group of diseases which are many of the time fetal for the patients due to problems associated with the oral conventional tablets. These problems can be overcome by this delivery system. With an increasing understanding of polymer behavior and the role of the biological factors, it is suggested that future research work on the way of floating drug delivery system should be aimed to control accurately the drug input rate into the gastrointestinal tract for the optimization of the pharmacokinetic and toxicological profiles of cardiovascular agents. This review gives an overview of cardiovascular disease, floating drug delivery system & role of floating drug delivery system in treatment of heart patient.