Abstract

Evaluation of Anti-Depressant Activity of Ethanolic Extract of Justicia gendarussa Burm with Wister Rat

Objective: Justicia gendarussa Burm is an herbal plant that has several therapeutic effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated anti-depressant effect of ethanolic extract from Justicia gendarussa Burm by using Forced Swimming Test (FST).

Methods: Two doses of ethanolic extract of Justicia gendarussa Burm (250 mg/kg and 500 mg/kg) was injected intraperitoneally. Immobility time and swimming time were measured after 30 min of injection and compared with negative control and imipramine as a positive control.

Results: The ethanolic extract (500 mg/kg) was found to be effective and it exhibited activity similar to that of the conventional drug imipramine (p<0.001) whereas 250 mg/kg dose showed higher activity with significantly increased swimming time and decreased immobility time than 500 mg/kg of ethanolic extract and imipramine.

Conclusion: These results proposed 250 mg/kg of ethanolic extract was showed higher anti-depressant activity than the standard.


Author(s):

Mythili A and Jothimanivannan C



Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+

Recommended Conferences

  • International Conference on Drug Discovery, Designing and Development
    June 27-28, 2018 Vancouver, British Columbia, Canada
  • World Drug Delivery Summit
    September 24-25, 2018 (10 Plenary Forums - 1Event) Chicago, Illinois, USA
  • International Conference on Pharmaceutical Chemistry
    October 29-31, 2018 Brussels, Belgium
Flyer image

Abstracted/Indexed in

  • Chemical Abstracts Service (CAS)
  • Index Copernicus
  • Google Scholar
  • Genamics JournalSeek
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • MIAR
  • ResearchGate
  • University Grants Commission