Curcumin (CUR) is considered of the main biological macromolecules, which is used in many foods and has an important role in the prevention of many diseases. A retrospective cohort study was performed, Sulfa drug (Sd) can cause perilous renal damages and there is no enough critical healing for Sd -induced renal damage. The work is aimed to induce nephrotoxicity through regulate the protective effects of curcumin (CUR) with Sulfa drug. Wistar Albino male rats have been administrated Sd to induce their Nephrotoxicity. "Malondialdehyde (MDA), glutathione (GSH) level and antioxidant enzyme activity" were measured in the renal tissue. Wherever, "urea, creatinine levels" were determined in the blood. Sulfa drug administration caused elevation of antioxidant enzyme activity, and levels of renal Malondialdehyde. CUR evidently was reduced the advancement of MDA levels, height antioxidant enzyme efficacy and maintained transformed renal morphology normally in administrated Sulfa drug animals.
Hanadi A Katouah