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RP-HPLC Method for the Simultaneous Estimation of Telmisartan and Hydrochlorothiazide in Pharmaceutical Dosage Form

A new simple, rapid, sensitive RP-HPLC method for the simultaneous determination of telmisartan and hydrochlorothiazide in pharmaceutical dosage forms was developed. Telmisartan has absorption maxima at 296 nm and hydrochlorothiazide has absorption maxima at 280 nm. For the simultaneous estimation of telmisartan and hydrochlorothiazide the detection wavelength was taken as 271 nm. Linearity for detector response was observed in the concentration range of 50 to 150 % of test concentration. Correlation coefficient (r) for calibration curve was found to be 1.0. Retention times were found to be 5.79 min and 2.85 min for telmisartan and hydrochlorothiazide respectively. Percent recovery was found to be with in the range of 98.0 % to 102.0%. The percent RSD for the analyzed tablet and recovery studied was less than 2. The results of recovery studies were found to be linear in the range 50 % to 150 % of test concentration. Results of the analysis were validated statistically and by recovery studies. The developed method was found to be precise, selective and rapid for the simultaneous determination of telmisartan and hydrochlorothiazide in bulk and in pharmaceutical dosage form.

Author(s): T. Gopala Swamya, K. Nagarajub and A. Lakshmana Rao

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