Efficient ocular drug delivery remains a challenge for pharmaceutical scientists. Most ocular diseases are treated by topical drug application in the form of solutions, suspensions, ointment and other drug delivery devices like inserts, implants, gelling systems, etc. These conventional and novel dosage forms suffer from the problems of poor ocular bioavailability, because of various anatomical and patho physiological barriers prevailing in the eye. This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings and applications of various nanoparticulate systems like nanosuspensions, nanoparticles, dendrimers, etc. and depicts how the various upcoming of nanotechnological approaches will be utilized to explore the frontiers of ocular drug delivery and therapy for the prolongation of residence time of the device to reduce the repeated instillation.
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