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Abstract

Formulation and Assessment of Lipid Based Formulation of Olmesartan Medoxomil

Olmesartan Medoxomil (OLM) is an angiotensin II receptor blocker antihypertensive agent. The aim of the present study investigation was to develop a Lipid Based Formulation (LBF) to enhance the dissolution as well as the oral bioavailability of poorly water soluble OLM. LBF classified into different four types. Among them Type I formulation and Type IV formulation was prepared. The solubility of OLM was determined in different oil, surfactant and co-surfactant. In Type I formulation, OLM (25mg) was dissolved in Capmul MCM C8 (500 mg) and sunflower oil (500 mg). LBFs were further evaluated for its percentage transmittance, Robustness to dilution, stability and drug content. The optimized formulation of OLMloaded LBF exhibited complete in vitro drug release in 120 min compared the plain drug. These results suggest the potential use of LBF to improve dissolution of poorly water soluble OLM


Author(s): MAULIK PATELA, MADHABHAI PATELB, NATVARBHAI PATELC, ANIL BHANDARID

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