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Effect of leaf extracts of Rhynchosia Beddomei on Ehrlich Ascites Carcinoma in mice

The leaf extracts of Rhynchosiae bedomei exhibited antitumor activities against Ehrlich Ascites Carcinoma in Swiss albino mice. Animals were treated with EAC cell lines (at a dose of 2 106 cells) and then after 24hrs, ethyl acetate and alcohol extract at a dose of 100mg and 200mg/kg, were administered for a period of 14 days. Later the mice were sacrificed for studying of antitumor activity. The decrement of tumor volume, packed cell volume and viable cell count were observed in both ethyl acetate and alcohol extract treated animals and compared with 5- fluorouracil treated and only EAC tumor bearing mice. Treatment with test compounds increased the survival time and restores the normal peritoneal cell count. Hematological parameters, PCV which were altered in EAC treated animals, were re-established considerably. Thus, the study is an attempt to evaluate the preventive and curative role of Rhynchosiae bedomei in tumor bearing mice.

Author(s): N.B.Sridharamurthy, R. Yogananda ,Dr. Riyaz Mahamood

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