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Development and validation of UV-Spectrophotometric method for determination of Cefuroxime Axetil in bulk and in Formulation

A simple, rapid, accurate and economical UVspectrophotometric method has been developed for estimation of Cefuroxime axetil from bulk and pharmaceutical formulation. The λmax of Cefuroxime axetil in 0.1N HCL was found to be 281 nm. The drug follows linearity in the concentration range 0.4 - 2 μg/ml with correlation coefficient value 0.998. The proposed method was applied to pharmaceutical formulation and % amount of drug estimated 99.19 % was found in good agreement with the label claim. The accuracy of the method was checked by recovery experiment performed at three different levels i.e., 80%, 100% and 120 %. The % recovery was found to be in the range 98.54%– 99.98%. The low values of % R.S.D. are indicative of the accuracy and reproducibility of the method. The precision of the method was studied as an intra-day, inter-day variations and repeatability. The % R.S.D. value less than 2 indicate that the method is precise. Ruggedness of the proposed method was studied with the help of two analysts. The above method was a rapid and cost-effective quality-control tool for routine analysis of Cefuroxime axetil in bulk and in pharmaceutical dosage form.

Author(s): Jain Pritam, Patel Manish, Surana Sanjay

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