The present work was planned to compare adaptogenic activity of ethanolic extracts of Holoptelea integrifolia (ETHEHI 250 mg/kg and ETHEHI 500 mg/kg) with Withania somnifera (ETHEWS 100 mg/kg) using forced swimming endurance test and Chronic cold restraint stress models. Based on the results, it can be concluded that both 250mg/kg and 500mg/kg doses of ethanolic extract of Holoptelea integrifolia showed adaptogenic activity and this activity was closer to the activity of 100mg/kg of Withania somnifera. The adaptogenic activity was dose dependent in ethanolic extract of Holoptelea integrifolia. These effects may be due to the presence of tannins, saponins, alkaloids, phenolics, flavonoids in the extract of bark of Holoptelea integrifolia as flavonoids, tannins and phenolics are mainly responsible for adaptogenic activity. Adaptogens have not only specific therapeutic effects in some stress induced and stress related disorders, but will also have an impact on the quality of life of patients.