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Anti-Inflammatory and Analgesic activity of Dl-Alpha-Tocopheryl Acetate and its interaction with aspirin in Wistar rats.

In the present study anti inflammatory activity of different doses of dl-alpha-tocopheryl acetate viz., 9,18,36 and 72 mg/kg is investigated in both acute and sub-acute models of inflammation in rats. Similarly their analgesic activity and effect on gastric ulcer were also studied. The study also aimed to elicit the possible interactions of dl-alpha-tocopheryl acetate with aspirin. Except 9 mg/kg, all the therapeutic equivalent doses of dl-alpha-tocopheryl acetate in acute model and in the dose of 36 and 72 mg/kg in sub-acute model of inflammation exerted significant anti-inflammatory activity. Combination of sub anti-inflammatory (SAI) dose of dl-alpha-tocopheryl acetate (9mg/kg) with that of aspirin (54mg/kg) showed significant anti-inflammatory activity in both the models of inflammation. Dl-alpha-tocopheryl acetate in the dose of 18, 36 and 72 mg/kg individually and its SAI dose when coadministered with that of aspirin showed significant analgesic activity at 1 and 3 hours. Dl-alpha-tocopheryl acetate in the dose of 36 and 72 mg/kg and combination treatment of SAI dose of dl-alpha-tocopheryl acetate with that of aspirin found to be gastroprotective. These findings clearly indicate the anti-inflammatory and analgesic activity of dl-alpha-tocopheryl acetate. In interaction studies, dl-alpha-tocopheryl acetate acts synergistically with aspirin towards reducing inflammation and pain as well as the former reduced the gastric ulcerogenic potential of the latter. If these findings are extrapolated to human beings, Vitamin E can be used individually or else as an adjuvant to NSAIDs in the treatment of inflammatory conditions. Clinical studies in this regard are really worthwhile

Author(s): Suneel. I. Majagi, T. N. Bhosle, P. A. Patil

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