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Abstract

Anti-Arthritic activity of Hydroalcoholic extract of Lawsonia Innermis

Adjuvant induced arthritis is a chronic crippling, skeletonmuscular disorder having nearest approximation to human rheumatoid arthritis for which there is currently no medicine available effecting a permanent cure. Even modern drugs used for the amelioration of the symptoms, offer only temporary relief and also produce severe side effects. This work was aimed at the scientific validation of the ethno-pharmacological claim about Lawsonia inermis and its anti-arthritic property. In the present study, antiarthritic activity of hydroalcoholic extract of Lawsonia inermis is done by Freund's adjuvant induced arthritis model and formaldehyde induced arthritis model. Paw edema, paw diameter and loss in body weight during arthritis condition was corrected on treatment with hydroalcoholic extract of Lawsonia inermis and Diclofenac. Biochemical parameters such as hemoglobin and erythrocyte sedimentation rate were estimated. Serum parameters such as SGOT, SGPT, ALP, and Total protein were also estimated for assessing the anti- arthritic potential of hydroalcoholic extract of Lawsonia inermis. The results of the current investigation concluded, hydroalcoholic extract of Lawsonia inermis possess a significant anti-arthritic activity against adjuvant induced arthritis and formaldehyde induced arthritis model and justifying its therapeutic role in arthritic condition. The observed antiarthritic activity may be due to the presence of phytoconstituents such as alkaloid and flavonoids.


Author(s): Kore K.J., Shete R.V., Desai N.V.

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