Multi-Approach preparation of solid dispersions for improving dissolution rate of Domperidone Maleate using different ratios of Polymers


  1. Department of Industrial Pharmacy, Bharat Institute of Technology, Hyd, Telangana, India.
  2. Department of Pharmaceutics, Bharat Institute of Technology, Hyd, Telangana, India.
  3. Department of Pharmaceutical Analysis, Bharat School of Pharmacy, Hyd, Telangana, India.
Corresponding Author: day Bhasker Goud G E-mail: [email protected] [email protected]
Date of Submission: 20-11-2014 Date of Acceptance: 29-11-2014 Conflict of Interest: NIL Source of Support: NONE
Copyright: © 2014 Uday Bhasker Goud G et al, publisher and licensee IYPF. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
Related article at Pubmed, Scholar Google


Purpose: The Purpose of the present study was to investigate the possibility of improving the dissolution rate of water insoluble antiemetic drug Domperidone maleate with two different polymers viz. PEG 6000, PVP K25 at different ratios by using various solid dispersion methods. Methods: Solid dispersions of Domperidone maleate were prepared using different ratios of PEG 6000, PVP K25 as carrier by using solvent evaporation method, fusion method and solvent melt method. Results: The prepared solid dispersions were characterized for their drug content, in-vitro solubility, in-vitro dissolution studies, FTIR spectroscopy and DSC were performed to identify physiochemical interaction between the drug and carrier and its effect on dissolution behavior. The prepared formulations showed marked improvement in the solubility and dissolution rate of drug which may be due to decrease in crystallinity of drug and additives. Formulation A4 with 1:4:1 of DOM: PEG6000: PVP K25 gave fast dissolution rate 92.56% of drug when compared to other formulations prepared by different methods at different ratios of pure drug and carriers. Conclusion: The prepared solid dispersion of the Domperidone maleate with PEG and PVP can improve the dissolution rate of the drug (formulation A4 containing 1:4:1). And it can be concluded the solvent evaporation method shows better results compared to fusion method and Solvent Melt method. The solubility and dissolution improvement order is found to be solid evaporation method>Solvent Melt method> fusion method.


Domperidone maleate, Solubility, Solid dispersion, evaporation method, fusion method, Solvent Melt method, PEG 6000, PVP K25.


The enhancement of oral bioavailability of poor water soluble drugs remains one of the most challenging aspects of drug development. Bioavailability can be defined as rate and extent at which the drug is delivered to the systemic circulation from dosage form and reaches the site of action to produce the desired effect. Hence for drug whose aqueous solubility is less will definitely create bioavailability problem and thereby effecting therapeutic efficiency, once if we are able to increase the aqueous solubility of a drug, the disintegration and dissolution properties can be easily altered, as a result, an increase in bioavailability can be easily achieved [1,2]. According to biopharmaceutical classification system (BCS), Domperidone maleate is classified under class-II (poor solubility and high permeability). It thus provides an excellent safety profile for long-term administration orally in the recommended doses [3]. Domperidone maleate, a dopamine D2 receptor antagonist, is used as a prokinetic and antiemetic agent for the treatment of gastro paresis, nausea and vomiting. Domperidone maleate has low absorbability after oral administration and undergoes extensive first pass metabolism. The poor aqueous solubility may be one possible reason for its low bioavailability (13-17%) [4, 5]. Many methods are available to improve dissolution rate, solubility characteristics, including salt formation, micronization, complexation, prodrug, addition of solvent or surface active agents and solid dispersions (SD). SD’s is one of these methods, which is most widely and successfully applied to improve the solubility, dissolution rates and consequently the bioavailability of poorly soluble drug [3].
Solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic matrix and a hydrophobic drug. The matrix can be either crystalline or amorphous. The drug can be dispersed molecularly, in amorphous particles (clusters) or in crystalline particles. Transformation of crystalline drug to amorphous drug upon solid dispersion formulation increases the dissolution rate [3]. Solid dispersion techniques have been used to increase the solubility of a poorly water soluble drug [3]. Solid dispersion is a viable and economic method to enhance bioavailability of poorly water soluble drug and also it overcomes the limitations of previous approaches.
Drug dissolution, absorption, drug bioavailability and clinical effect were observed to be significantly greater than conventional dosage form by preparing solid dispersion mathod. The prepared material used in the preparation of orodispersible tablets and mouth dissolving films etc [4].
The objective of this study is to improve the solubility and dissolution rate of poorly water soluble drug Domperidone maleate by preparing Solid dispersion with PEG 6000 and PVP K25 as carriers. The prepared Solid dispersions were evaluated for solubility and in-vitro dissolution rate studies and absence of any interaction between the drug and polymer was confirmed using FTIR spectral studies and DSC [3].
Bio-pharmaceutics classification system for drugs[3]



Domperidone maleate a gift sample from the Lupin Pharmaceutical Pvt Ltd, India. PEG 6000 and PVP K 25 were procured from commercial sources. All other chemicals procured were of analytical reagent grade.


Preformulation study for drug-excipient compatability

The spectrum analysis of pure drug, polymer and physical mixtures of drug and different excipients used for preparation of Solid Dispersions was studied by FTIR. Spectra were recorded by preparing drug potassium bromide (KBr) discs using a Shimadzu Corporation (Koyto, Japan) facility (model - 8400S). The resultant disc was mounted in IR spectrophotometer and the spectrum was recorded from 4000 cm-1 to 500 cm-1 for 12 minutes [4].

Preparation of Solid Dispersions

Solvent Evaporation Method: The physical mixture of the drug and two different water soluble carriers with different concentrations are dissolved in different beakers containing common solvent and the resulting clear solution is rapidly heated for evaporating the solvent to get a glassy solid mass (Table 1). Briefly, the water soluble polymer was dissolved in 20% ethanol under stirring, until a clear solution was obtained; Domperidone maleate was then added and stirring was continued for 45 min. The organic solvent was removed by evaporation on a water bath at 60°C. The resultant solid dispersions were stored in desiccators until constant mass was obtained, pulverized and passed through sieve No. 22 [5]. Fig.1
Fusion Method: The polymer PEG 6000 and PVP K25were melted at 60°C and then the drug was added, mixed well and cooled in an ice bath to obtain a solid mass (Table 1). The solidified mass was crushed and passed through a sieve No. 22. The resulting solid dispersion was stored in desiccators until used [5] Fig. 2.
Solvent Melt Method: Solid dispersions of drug with PEG 6000 and PVPK25 were prepared by meltsolvent method (Table 1). In this method, drug was dissolved in methanol and the solution was incorporated into the melt of PEG 6000 and PVPK25at 165°, by pouring into it. It was then kept in an ice bath for sudden cooling. The mass was kept in the desiccators for complete drying. The solidified mass was scrapped, crushed, pulverized and passed through sieve No. 22 [5] Fig.3.

Calibration curve for domperidone maleate:

UV Spectrum: Form stock solution in 6.8 phosphate buffer, serial dilutions were done get a concentration of 10μg/ml. UV scan range was taken between the wavelengths 200-400 nm. max was observed at 287 nm. Calibration Curve in 6.8 phosphate buffer solutions was plotted with concentrations of 2, 4, 6, 8, and 10μg/ml. Absorbance of these solutions was measured against a blank of 6.8 phosphate buffers at 287 nm Fig.4.

Evaluation tests

Determination of Melting Point

The melting point of Domperidone maleate and formulations was determined by capillary tube method. A small quantity of powder was placed into a capillary tube and the tube was placed in the capillary melting apparatus and the temperature was gradually increased automatically. The temperature at which powder started to melt and the temperature when all the powder gets melted were observed [7].

% Solubility Study

The Solubility of domperidone maleate was carried out by adding an amount of the prepared formulas equivalent to 5 mg of the drug to 10 ml of 6.8 phosphate buffer solutions in conical flask covered with foil and shacked at 37°C for 1 hr. The samples were filtered, properly diluted and analyzed spectrophotometrically at 287 nm to measure the amount of dissolved domperidone maleate [1, 8].

Determination of percent yield

The percent yield of domperidone maleate solid dispersions can be determined by using the following expression [9, 10].
Percent yield = (weight of prepared solid dispersion / weight of drug + carriers) x 100

Drug Content Estimation

The drug contents in solid dispersion were determined by the UV-spectroscopic method. An accurately weighed quantity of solid dispersion equivalent to 10 mg of domperidone maleate was transferred to a 100 ml volumetric flask containing 20 ml of Dimethylformamide (DMF) and dissolved. The solution was filtered through 0.45μm membrane filter paper. One ml of thissolution was diluted 100 times with same solvent Dimethylformamide (DMF): distilled water (20:80) and the absorbance was measured at 287 nm [11].

Dissolution studies

The dissolution of domperidone maleate from these elected formulas and the corresponding physical mixtures as well as the drug alone were studied using the U.S.P 25 dissolution apparatus II (paddle type). Accurately weighed amounts equivalent to 10 mg of domperidone maleate were dispersed in 500 ml of the dissolution medium (phosphate buffer pH 6.8) at 37±0.5°Cstirred at 100 rpm. At appropriate time intervals, samples (5 ml) were withdrawn over a period of 1 hour and replaced by an equal volume of fresh buffer. The samples were filtered and the drug content was determined spectrophotometrically at 287 nm, all experiments were carried out in triplicate [12]. And the results presented in table no 7.


FT-Infra Red and DSC Studies for Drug-Excipient Compatibility

DSC spectra for Domperidone maleate and all the solid dispersions of different preparation method show that there was no interaction between them In comparison with pure drug the absorption peak of the FT-IR spectra for Domperidone maleate showed no significant shift and no disappearance of characteristic peaks in all the preparations of different methods suggesting that there is no interaction between drug and polymers or no degradation in Domperidone maleate molecule Fig. 5-6, 7-8.The differences in transmittance may be due to varied concentration of drug.

Percentage Yield

The percent yield of Domperidone maleate solid dispersions ranged between 96 to 98%.The results are shown in (Table 2- 4) Fig.9

Drug content

The drug content of the solid dispersions was found to be between 95.93 and 98.93% (Table 2- 4). Fig.9

Determination of Melting Point

Domperidone maleate is a white, crystalline odour less powder. Melting point the drugs was determined by using melting Point determination apparatus, the melting point range was between 240 -2420C.The results of melting points of various solid dispersions are shown in (Table 2- 4), Fig.9

Solubility studies

The solubility of Domperidone maleate in 6.8 phosphate buffer solutions is 32.52 μg/ml. The results show more solubility of solid dispersions compared to pure drug in 6.8 phosphate buffer solutions that might be due to formation of complexes between drug, PEG 600 and PVPK 25. Formulations prepared by solvent evaporation method A1 to A5show more solubility compared to solid dispersions prepared by other methods. In this formulations A4containingdrug: PEG 6000:PVPK25 at ratio1:4:1shows more solubility. The solubility of formula A4 is 92.91μg/ml. The results are shown in (Table 5) Fig.10.

Dissolution Studies

From the In-vitro study, it can be clearly observed that the dissolution rate of pure drug was low i.e., 30.10% of drug dissolved in 60 min. There was marked increase in the dissolution rate of Domperidone maleate from all the solid dispersions when compared to pure Domperidone maleate itself. Among the three solid dispersion preparation methods, highest dissolution was observed in solid dispersions prepared by the solvent evaporation method. The results are shown in table 6-.The increased dissolution rate may be attributed to the increased drug wet ability, decreased particle size, conversion to amorphous form and solubilization of the drug due to hydrophilic carrier. The formulation (A4) 1:4:1 of DOM: PEG: PVP gives fast dissolution rate 85.77% of drug in pH 6.8 Phosphate media as compared to all other formulations and pure drug in one hour. The order of efficiencies of products based on percentage drug release after 60 minutes is A4> C4> B4> A5> C5> B5> A3> C3> B3> A2> C2> B2> A1> C1> B1> Pure drug. Fig. 11-14.


Development of Domperidone maleate prepared with PEG 6000 and PVP K25 showed high percentage yield and drug content in solid all dispersions. FT-IR and DSC studies have shown no interaction between the drug, polymer and the solid dispersion preparation. The in-vitro dissolution test showed a significant increase in the dissolution rate of solid dispersions as compared with pure Domperidone maleate. It was evident that the solid dispersion (SD) technique had improved the dissolution rate of drug to agreat extent. Solid dispersion of Domperidone maleate using hydrophilic polymeric carriers would improve the aqueous solubility, dissolution rate and thereby enhancing its systemic availability. The solubility and dissolution rates of Domperidone maleate were high in the solid dispersions prepared by solvent evaporation method with ratio of drug: PEG6000: PVP k25 at 1:4:1.Therefore solid dispersion by solvent evaporation method can be an effective way to improve the bioavailability of poor water soluble drugs like Domperidone maleate.


The authors are thankful to Lupin Pharmaceutical Pvt Ltd, India, for generously giving the samples of domperidone maleate . We are also grateful to the Principal and Management of Bharat Institute of Technology, Hyderabad for their constant encouragement.

Tables at a glance

Table icon Table icon Table icon
Table 1 Table 2 Table 3
Table icon Table icon Table icon
Table 4 Table 5 Table 6

Figures at a glance

Figure 1 Figure 2 Figure 3 Figure 4 Figure 5
Figure 1 Figure 2 Figure 3 Figure 4 Figure 5
Figure 6 Figure 7 Figure 8 Figure 9 Figure 10
Figure 6 Figure 7 Figure 8 Figure 9 Figure 10
Figure 11 Figure 12 Figure 13 Figure 14
Figure 11 Figure 12 Figure 13 Figure 14


1) Veer Reddy K, Amit Kumar, TulaseeLalitha R, Bhaskara Reddy N, Vijaya Lakshmi M and TulasiMaheswari M: Development of Domperidone Mouth Dissolving Tablets Using Solid Dispersion Technique. International Journal of Research in Pharmaceutical and Biomedical Sciences 2013; 4 (3): 702-708.

2) Ahuja N, Katare OP and Singh B: Studies on dissolution enhancement and mathematical modelling on drug release of poorlywatersoluble drugs using water soluble carriers. Eur J Pharm Biopharm 2007; 65: 26-38.

3) UdayBhaskerGoud G, Uday Kumar Reddy ,A.Pranav Kumar, G.R.Sreenivas Reddy. and J.S.V. Prakash: Solubility and Dissolution enhancement of poorly water soluble drug Aceclofenac by solid dispersion method. Int. J. Pharm. Life Sci. 2014; 5(8): 3727-3733.

4) UdayBhaskerGoudGoundla, Jakkampudi Sri Venu Prakash, PranavKumarAvadhanam, SreenivasReddyGangi Reddy, ManikantaSaiKrashna, PangaJanakiRamulu: pharmaceutical evaluation of different super disintegrants in design of metoprolol tartrate orodispersible tablets. world journal of pharmaceutical research 2014;3(8): 627-639.

5) G. Poovi, M.Umamaheswari, S. Sharmila, Sujit Kumar and A.N. Rajalakshmi: Development of Domperidone Solid Dispersion Powders Using Sodium Alginate as Carrier. European Journal of Applied Sciences 2013; 5 (2): 36-42.

6) Reddymasu, C., I. Soykan and R.W. McCallum: Domperidone review of pharmacology and clinical applications in gastroenterology. Amer. J. Gastroenterol. 2007; 102: 2036-2045.

7) D.k. Sanghi and rakeshtiwle: phase solubility study of hydrophobic drug domperidone using a novel technique inclusion complex with _- cyclodextrine, 2014; 4(3): 157-162.

8) S. LakshmanaPrabu, A. Shirwaikar, A. Shirwaikar, C. Dinesh Kumar, A. Josephand R. Kumar: Simultaneous estimation of esomeprazole and domperidone by UV spectrophotometric method. Indian J.Pharm. Sci. 2008; 70 (1): 128- 131.

9) Tyagireena, dhillonvandana: enhancement of solubility and dissolution rate of domperidone using cogrinding and kneading technique. Journal of drug delivery & therapeutics 2012; 2(4): 152-158.

10) Dixit AK, Singh RP, Singh S: Solid dispersion – A Strategy for improving the solubility of poorly soluble drugs, IJRPBS, 3(2), 960-966.

11) RajenderGuleria, NS Kaith, Ranjit Singh: Improved dissolution of domperidone in solid dispersion with polymeric hydrophillic additive, Journal of Chemical and Pharmaceutical Research 2011; 3(6): 655-664.

12) E. H. Ibrahim, t. H. El-faham, f.a. mohammed, n. S. El-eraky: enhancement of solubility and dissolution rate of domperidone by utilizing different techniques. Bull. Pharm. Sci., Assiut University (2011); 34(2): 105-120.
Select your language of interest to view the total content in your interested language

Viewing options

Recommended Conferences
Flyer image
journal indexing image

Share This Article


tempobet giriş

tempobet giriş

tipobet süpertotobet yeni adres süperbahis 747 güvenilir bahis siteleri telefonda sex sohbet