A COMPARATIVE STUDIES OF THE ACTION OF GLUCOSE AND SCOPOLAMINE ON THE COGNITIVE FUNCTION OF ALBINO RATS USING DIGITAL ZERO MAZE APPARATUS

Jain Deepak, Singh Vinay R*, Verma Sofiya, Yadav Priyanka
Shri Ram Institute of Technology, Jabalpur (M.P.)
 
Corresponding Author : Singh Vinay R, Shri Ram Institute of Technology, Jabalpur (M.P.)
 
Received: 12 December 2010
Accepted: 22 January 2011
 
Related article at Pubmed, Scholar Google
 

Abstract

Objective: The Purpose of the Present study was to compare the action of glucose and scopolamine on the cognitive function using digital zero maze apparatus on albino rats.

Method: The digital zero mazes was made of ply-wood in which to arms positioned at right angled related to each other .This apparatus is like a digital zero maze digit in appearance. Albino rats were given a free exploration session consisting of 10 minutes in the apparatus 24 prior to testing to allow familition to the testing apparatus. Albino rat was treated with glucose to determine the memory performance in second trials scopolamine was injected and effect was observed.

Result: In the present study 2 groups were taken and had given treatment glucose and scopolamine (buscopan).The digital zero maze was design to study animal behavior after supervised training given to the rats the observation glucose and scopolamine were shows that the glucose a have some sought of cognition enhancing activity in experiment animals On the other hand the scopolamine slows down cognition activity of brain.

Conclusion: The result shows that glucose enhanced the activity while scopolamine slows down cognition activity of brain.

Key words

 
Cognition , Scopolamine, Albino rat, Exploration, Digital zero maze apparatus
 

Introduction

 
The term cognition (Latin: cognoscere, "to know", "to conceptualize" or "to recognize") refers to a faculty for the processing of information, applying knowledge, and changing preferences. Cognition, or cognitive processes, can be natural or artificial, conscious or unconscious [1] [2]. These processes are analyzed from different perspectives within different contexts, notably in the fields of linguistics, anesthesia, neurology, psychology, philosophy, anthropology, systemic and computer science. Within psychology or philosophy, the concept of cognition is closely related to abstract concepts such as mind, reasoning, perception, intelligence, learning, and many others that describe capabilities of the mind and In psychology and in artificial intelligence, cognition is used to refer to the mental functions, mental processes (thoughts) and states of intelligent entities (humans, human organizations, highly autonomous machines).[1][4-6]. In particular, the field focuses toward the study of specific mental processes such as comprehension, inference, decision-making, planning and learning. Recently, advanced cognitive research has been especially focused on the capacities of abstraction, generalization, concretization/specialization and meta-reasoning.[7] This involves such concepts as beliefs, knowledge, desires, preferences and intentions of intelligent individuals, objects, agents or systems. The concept of cognition is closely related to such abstract concepts as mind, reasoning, perception, intelligence, learning, and many others that describe numerous capabilities of the human mind and expected properties of artificial or synthetics intelligence.[8] The consistent neuropath logical occurrence associated with memory is a cholinergic deficit, which has been correlated with severity of AD.[9] The aim of this study was to compare the cognition activity of glucose and scopolamine on albino rats using digital zero maze apparatus.
 

Material and Methods

 
Drugs: Control (normal saline), Glucose (0.04mg/kg) and scopolamine (buscopan20mg/ml) amp. Were used in the experiment.
 
Animals: Young albino male rats (72-80gm) were used the animal were housed under standard laboratory condition and facility on a 12:12 hrs light /dark cycle. All the in vivo experiment were carried out between 8.00amto5:30pm each day (light cycle).
 
Apparatus: Digital zero maze apparatus.
 

Method:

 
24 mice were taken and divided into 3 groups of 8 animals each. 4 anticlockwise and 4 clockwise were trained using apparatus. Group1, animals were injected with Normal Saline. Group 2 animal were injected with glucose (0.04mg/kg)for 4 week in both direction (clockwise and anticlockwise). Group 3 animals were injected with scopolamine (buscopan 20mg/ml I.P) for 4 week in clockwise and anticlockwise direction. The apparatus was kept at a place where there were minimal noise distractions. 24 rats were taken, and were numbered, weighed and divided into 3 Groups. The maze was marked by maker for the clockwise and anticlock direction. The rats were exposed to the apparatus to get accosted to the apparatus. Food were used to train the rat was kept at the end point. Than concurrent steps repeated for all the 24 rats in 3 groups’ .The rats were trained for 5 to 6 days with food. Expoure of rats as not more than two minutes After this training glucose and scopolamine was injected in separated groups of rats .Now the rats was kept again starting point one by one and door was opened in their respective clockwise and anticlockwise direction. Reading was noted down.
 
Summary: Study Duration: 4 weeks, Group Description: A Group of 8 male Rat’s weight between 70-8 gm, 1st Group: control (Normal Saline), 2nd Group: Glucose Treated, 3rd Group: Scopolamine Treated.
 

Result and Discussion

 
In the present study 3 groups were taken and had given treatment glucose and scopolamine (buscopan). The digital zero maze was design to study animal behavior after supervised training given to the rats the observation glucose and scopolamine were shows that the glucose a have some sought of cognition enhancing activity in experiment animals On the other hand the scopolamine slows down cognition activity of brain.
 

Conclusion

 
The result clearly that the Glucose have some sought of cognition enhancing activity in experimental animal. On the other hand the Depressive Scopolamine slows down cognition activity of brain. So never wonder if candy in your mouth helps you to perform better in Examination.
 

Conflict of Interest

 
NIL
 

Source of Support

 
NONE
 

Tables at a glance

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