Systemic lupus erythematous (SLE) is a multisystem autoimmune disorder that predominantly affects females in their reproductive years and fertility can be negatively affected by disease activity (autoimmune oophoritis) or by the gonadotropic medications used. Pregnancies in SLE are also associated with higher neonatal and maternal complications. Neonates born to mothers with SLE are more likely to be preterm, have a low birth weight and are associated with stillbirth compared to neonates born to healthy control mothers.
Iman Mohammed Reda Ibrahim Abdel Fattah kandil