Reach Us +44-7480-022449




Here an attempt has been made to synthesize fourteen 5-methylpyrazine-2-carbohydrazide derivatives. The synthesized derivatives were assessed for their in-vitro anti-bacterial activity and minimum inhibitory concentration (MIC) against Gram-positive strains (Staphylococcus aureus and Bacillus subtilis) and Gram-negative strains (Salmonella typhi and Escherichia coli). During the present work, 5-methylpyrazinoic acid was esterified with ethanol to get ethylpyrazinoate and it refluxed with hydrazine hydrate to yield the 5-methylpyrazinoic acid hydrazide. The obtained acid hydrazide was then condensed with various substituted aromatic aldehydes to yield various 5-methylpyrazine-2- carbohydrazide derivatives. The structures of newly synthesized compounds so obtained were confirmed by using IR, 1HNMR, MS spectral data. All compounds gave satisfactory elemental analyses. The compounds PM 8-10, (i.e. 2,3 and 4- nitro benzaldehyde derivatives respectively) showed promising activity amongst the compounds tested against both the Gram-positive and Gram-negative strains tested. .

Select your language of interest to view the total content in your interested language

Viewing options

Post your comment

Share This Article

Flyer image
journal indexing image

Post your comment

captcha   Reload  Can't read the image? click here to refresh